SAFE
5-HTP Sleep Formula
5-HTP with B6 sleep complex
Possibly Safe
V1 Verified
Sleep Support
PubMed Studies
2,800
About
5-HTP (100mg) with Vitamin B6 (P-5-P) for enhanced serotonin and melatonin synthesis. Used for insomnia and depression.
How it works (mechanism of action)
Modulates GABAergic neurotransmission via GABA-A receptor allosteric modulation or GABA transaminase inhibition increasing inhibitory CNS tone. Activates melatonin synthesis or MT1/MT2 receptor pathways, or reduces cortisol secretion by modulating HPA axis activation.
👥 Safety by Population
🚫 Contraindications & Warnings
Serotonin syndrome risk. Not with SSRIs. Cardiac valvulopathy: theoretical risk at high doses.
🏷️ Other Names
5-HTP with B6 sleep complex